| First Author | Hattori M | Year | 1986 |
| Journal | Science | Volume | 231 |
| Issue | 4739 | Pages | 733-5 |
| PubMed ID | 3003909 | Mgi Jnum | J:29570 |
| Mgi Id | MGI:77101 | Doi | 10.1126/science.3003909 |
| Citation | Hattori M, et al. (1986) The NOD mouse: recessive diabetogenic gene in the major histocompatibility complex. Science 231(4739):733-5 |
| abstractText | Examination of the histocompatibility region of the nonobese diabetic (NOD) mouse with antibodies against class II glycoproteins (products of immune response genes of the major histocompatibility complex I-A and I-E), hybrid T-cell clones, and mixed-lymphocyte cultures and analysis of restriction fragment length polymorphisms indicate that the NOD mouse has a unique class II major histocompatibility complex with no expression of surface I-E, no messenger RNA for I-E alpha, and an I-A not recognized by any monoclonal antibodies or hybrid T-cell clones studied. In crosses of NOD mice with control C3H mice, the development of diabetes was dependent on homozygosity for the NOD mouse's unique major histocompatibility region. |
