| Primary Identifier | MGI:107721 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 110084 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Acts upstream of or within epithelial cilium movement involved in extracellular fluid movement and flagellated sperm motility. Located in extracellular region and sperm flagellum. Is expressed in cerebellum; choroid plexus; and lateral ventricle choroid plexus. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 37 and spermatogenic failure 18. Orthologous to human DNAH1 (dynein axonemal heavy chain 1). PHENOTYPE: Homozygous null mice show male sterility, asthenospermia, and reduced beat frequency in tracheal cilia. Males homozygous for an ENU-induced mutation are sterile with abnormal sperm clumping behavior, asthenospermia, low in vitro fertilization rate, and impaired sperm penetration of zona pellucida. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
