| Primary Identifier | IPR034648 | Type | Domain |
| Short Name | CELF3/4/5/6_RRM1 |
| description | This entry represents the RNA recognition motif 1 (RRM1) of CELF-3, CELF-4, CELF-5, CELF-6, all of which belong to the CUGBP1 and ETR-3-like factors (CELF) or BRUNOL (Bruno-like) family of RNA-binding proteins [, ]. The CELF family members have three RRMs []. It has been shown that either RRM1 or RRM2 of CELF-4 are necessary and sufficient for muscle-specific splicing enhancer (MSE) RNA binding []. The human CELF family has six members, which can be divided into two subfamilies based on their phylogeny: CELF1-2 and CELF3-6. They all possess alternative splicing activity in the nucleus and all have cytoplasmic roles, including regulating mRNA adenylation status, stability, and translation in various cell types []. |
