| First Author | Gerlach C | Year | 2016 |
| Journal | Immunity | Volume | 45 |
| Issue | 6 | Pages | 1270-1284 |
| PubMed ID | 27939671 | Mgi Jnum | J:259933 |
| Mgi Id | MGI:6141041 | Doi | 10.1016/j.immuni.2016.10.018 |
| Citation | Gerlach C, et al. (2016) The Chemokine Receptor CX3CR1 Defines Three Antigen-Experienced CD8 T Cell Subsets with Distinct Roles in Immune Surveillance and Homeostasis. Immunity 45(6):1270-1284 |
| abstractText | Infections induce pathogen-specific T cell differentiation into diverse effectors (Teff) that give rise to memory (Tmem) subsets. The cell-fate decisions and lineage relationships that underlie these transitions are poorly understood. Here, we found that the chemokine receptor CX3CR1 identifies three distinct CD8(+) Teff and Tmem subsets. Classical central (Tcm) and effector memory (Tem) cells and their corresponding Teff precursors were CX3CR1(-) and CX3CR1(high), respectively. Viral infection also induced a numerically stable CX3CR1(int) subset that represented approximately 15% of blood-borne Tmem cells. CX3CR1(int) Tmem cells underwent more frequent homeostatic divisions than other Tmem subsets and not only self-renewed, but also contributed to the expanding CX3CR1(-) Tcm pool. Both Tcm and CX3CR1(int) cells homed to lymph nodes, but CX3CR1(int) cells, and not Tem cells, predominantly surveyed peripheral tissues. As CX3CR1(int) Tmem cells present unique phenotypic, homeostatic, and migratory properties, we designate this subset peripheral memory (tpm) cells and propose that tpm cells are chiefly responsible for the global surveillance of non-lymphoid tissues. |
