| First Author | Hursting SD | Year | 2007 |
| Journal | Cancer Res | Volume | 67 |
| Issue | 6 | Pages | 2391-3 |
| PubMed ID | 17363554 | Mgi Jnum | J:120336 |
| Mgi Id | MGI:3706288 | Doi | 10.1158/0008-5472.CAN-06-4237 |
| Citation | Hursting SD, et al. (2007) The obesity-cancer link: lessons learned from a fatless mouse. Cancer Res 67(6):2391-3 |
| abstractText | Current dogma suggests that the positive correlation between obesity and cancer is driven by white adipose tissue that accompanies obesity, possibly through excess secretion of adipokines. Recent studies in fatless A-Zip/F1 mice, which have undetectable adipokine levels but display accelerated tumor formation, suggest that adipokines are not required for the enhanced tumor development. The A-Zip/F-1 mice are also diabetic and display elevated circulating levels of other factors frequently associated with obesity (insulin, insulin-like growth factor-1, and proinflammatory cytokines) and activation of several signaling pathways associated with carcinogenesis. In view of this information, the risk factors underlying the obesity-cancer link need to be revisited. We postulate that the pathways associated with insulin resistance and inflammation, rather than adipocyte-derived factors, may represent key prevention and therapeutic targets for disrupting the obesity-cancer link. |
