| Primary Identifier | MGI:1349475 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 26931 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable protein phosphatase activator activity. Predicted to be involved in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; and negative regulation of cell population proliferation. Predicted to act upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in Golgi apparatus; chromosome, centromeric region; and nucleoplasm. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including central nervous system; eye; genitourinary system; heart; and hemolymphoid system gland. Orthologous to human PPP2R5C (protein phosphatase 2 regulatory subunit B'gamma). PHENOTYPE: Mice homozygous for a gene-trapped allele show partial neonatal lethality, hypoactivity, and abnormal ventricular septum formation associated with increased fetal cardiomyocyte apoptosis. Surviving homozygotes develop obesity and show an abnormal gait, decreased grip strength, and impaired balance. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
