| Primary Identifier | IPR031738 | Type | Domain |
| Short Name | JMY/WHAMM |
| description | JMY (junction-mediating and -regulatory protein) []and WHAMM (WASP homologue-associated protein with actin, membranes and microtubules) []are two nucleation-promoting factors (NPFs) with similar domain architecture. JMY was originally identified as a transcriptional co-factor in the p53-response to DNA damage. Aside from this nuclear function, JMY is involved in cytoskeleton remodelling and trans-Golgi transport []. WHAMM binds microtubules and is involved in ER to cis-Golgi transport []. JMY and WHAMM show similar localisation and could be involved in similar processes []. This middle domain is the coiled-coil region that putatively binds microtubules to the scaffold. This ability to interact with microtubules plays a role in membrane tubulation. |
