| Primary Identifier | MGI:108554 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 13131 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable phosphatidylinositol 3-kinase binding activity. Involved in lateral motor column neuron migration; regulation of synapse maturation; and ventral spinal cord development. Acts upstream of or within several processes, including adult walking behavior; negative regulation of neurogenesis; and nervous system development. Located in perinuclear region of cytoplasm. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 37. Orthologous to human DAB1 (DAB adaptor protein 1). PHENOTYPE: Homozygous null display unstable gait and whole-body tremor with a hypoplastic cerebellum devoid of folia, a probable consequence of defective neuronal migration. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
