| First Author | Penha-Gonçalves C | Year | 1995 |
| Journal | Genomics | Volume | 28 |
| Issue | 3 | Pages | 398-404 |
| PubMed ID | 7490073 | Mgi Jnum | J:28399 |
| Mgi Id | MGI:76017 | Doi | 10.1006/geno.1995.1167 |
| Citation | Penha-Goncalves C, et al. (1995) Type 1 diabetes and the control of dexamethazone-induced apoptosis in mice maps to the same region on chromosome 6. Genomics 28(3):398-404 |
| abstractText | Quantitative trait loci mapping was used to identify the chromosomal location of genes that contribute to increase the resistance to apoptosis induced in immature CD4+8+ thymocytes. An F2 intercross of the nonobese diabetic (NOD) mouse (displaying an apoptosis-resistance phenotype) and the C57BL/6 mouse (displaying a nonresistance phenotype) was phenotypically analyzed and genotyped for 32 murine microsatellite polymorphisms. Maximum likelihood methods identified a region on the distal part of chromosome 6 that is linked to dexamethazone-induced apoptosis (lod score = 3.46) and accounts for 14% of the phenotypic variation. This chromosomal region contains the diabetes susceptibility locus Idd6, suggesting that the apoptosis-resistance phenotype constitutes a pathogenesis factor in IDDM of NOD mice. |
