| First Author | DiPaolo RJ | Year | 2002 |
| Journal | J Immunol | Volume | 169 |
| Issue | 6 | Pages | 2832-6 |
| PubMed ID | 12218093 | Mgi Jnum | J:120434 |
| Mgi Id | MGI:3706586 | Doi | 10.4049/jimmunol.169.6.2832 |
| Citation | DiPaolo RJ, et al. (2002) Cutting edge: the relative distribution of T cells responding to chemically dominant or minor epitopes of lysozyme is not affected by CD40-CD40 ligand and B7-CD28-CTLA-4 costimulatory pathways. J Immunol 169(6):2832-6 |
| abstractText | We examined the frequencies and specificities of the CD4+ T cell responses to the protein hen egg white lysozyme in mice deficient in the CD40-CD40 ligand or B7-CD28 costimulatory pathways. The frequency of T cells was decreased by between 3- and 4-fold in CD40-/- mice, and 12-fold in B7-1/B7-2-/- mice, but surprisingly, the relative distribution of T cells responding to peptides that were presented at levels that differed by >250-fold was similar. We also examined the CD4 response after blocking the regulatory molecule CTLA-4 during immunization. We observed no difference in either the frequency or specificity of the CD4+ T cell response if CTLA-4 was blocking during priming. Thus, the T cell response was generated toward the constellation of chemically dominant and subdominant epitopes as a whole, and did not discriminate among them based on their relative abundance. |
