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Protein Coding Gene : Ltbr lymphotoxin B receptor
Primary Identifier  MGI:104875 Organism  mouse, laboratory
Chromosome  6 NCBI Gene Number  17000
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable identical protein binding activity and ubiquitin protein ligase binding activity. Acts upstream of or within myeloid dendritic cell differentiation. Predicted to be located in Golgi apparatus. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and long bone. Orthologous to human LTBR (lymphotoxin beta receptor).
PHENOTYPE: Homozygotes for a targeted null mutation lack Peyer's patches, colon-associated lymphoid tissues, and lymph nodes. Mutants also exhibit severely reduced numbers of NK cells and increased susceptibility to Theiler's murine encephalomyelitis virus. [provided by MGI curators]
  • synonyms:
  • TNF receptor-related protein,
  • lymphotoxin A receptor,
  • tumor necrosis factor receptor 3,
  • MGI:104851,
  • Tnfbr,
  • AI256028,
  • LT beta-R,
  • Ltbr,
  • LT-beta receptor,
  • Tnfrsf3,
  • TNF-R-III,
  • TNFCR,
  • MGD-MRK-19752,
  • LTbetaR,
  • expressed sequence AI256028,
  • lymphotoxin B receptor,
  • TNFRrp,
  • MGI:893576,
  • tumor necrosis factor beta receptor,
  • TNFR2-RP,
  • MGI:2141385,
  • MGD-MRK-28175,
  • Ltar,
  • MGD-MRK-28148,
  • tumor necrosis factor receptor superfamily, member 3
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