| Primary Identifier | MGI:1097680 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 12267 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable G protein-coupled receptor activity; complement component C3a binding activity; and complement receptor activity. Involved in positive regulation of angiogenesis; positive regulation of vascular endothelial growth factor production; and regulation of granulocyte chemotaxis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including bladder; blood; cerebral cortex; gut; and male reproductive gland or organ. Human ortholog(s) of this gene implicated in asthma. Orthologous to human C3AR1 (complement C3a receptor 1). PHENOTYPE: Homozygous targeted mutants display protective effects against the changes in lung physiology after allergen challenge, increased lethality to endotoxin shock, and elevated IL1B following LPS challenge, supporting the role of C3arin proinflammatory responses. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
