| First Author | Harper S | Year | 1990 |
| Journal | Development | Volume | 110 |
| Issue | 2 | Pages | 515-9 |
| PubMed ID | 2133552 | Mgi Jnum | J:32543 |
| Mgi Id | MGI:80037 | Doi | 10.1242/dev.110.2.515 |
| Citation | Harper S, et al. (1990) NGF mRNA expression in developing cutaneous epithelium related to innervation density. Development 110(2):515-9 |
| abstractText | To determine if the initial level of NGF mRNA in developing cutaneous epithelium is correlated with its final innervation density, we measured the concentration of NGF mRNA in the epithelia of the maxillary, mandibular and ophthalmic territories of trigeminal ganglion in the embryonic mouse. At the onset of neuronal death in the ganglion there were marked differences in the concentration of NGF mRNA in these epithelia: the level was highest in the epithelium of the densely innervated maxillary territory, it was lower in the epithelium of the moderately innervated mandibular territory and was lowest in the epithelium of the sparsely innervated ophthalmic territory. These regional differences in the level of NGF mRNA during the early stages of target field innervation suggest that the level of NGF production in target field cells, rather than regional differences in the access of innervating neurons to NGF, governs the number of neurons that survive. Because the same percentage cell death occurs in each of the subsets of trigeminal neurons that innervate the maxillary, mandibular and ophthalmic territories, regional differences in NGF synthesis are not responsible for establishing differences in innervation density, rather they maintain differences that arise earlier in development. |
