| First Author | Yoshida T | Year | 1996 |
| Journal | Biochem Biophys Res Commun | Volume | 228 |
| Issue | 1 | Pages | 216-20 |
| PubMed ID | 8912662 | Mgi Jnum | J:36625 |
| Mgi Id | MGI:84052 | Doi | 10.1006/bbrc.1996.1642 |
| Citation | Yoshida T, et al. (1996) The BCL6 gene is predominantly expressed in keratinocytes at their terminal differentiation stage. Biochem Biophys Res Commun 228(1):216-20 |
| abstractText | We analyzed the expression of the BCL6 gene in mouse tissues by in situ hybridization. The expression was strong in the upper layer but undetectable in the basal layer of epidermis from adult mice. When human keratinocytes were cultured with a high concentration of calcium ion, these cells stopped their proliferation and differentiated to their terminal stage. In these keratinocytes, BCL6 expression was induced after stimulation and progressively up-regulated. The kinetics was very similar to that of a cyclin dependent kinase inhibitor p21sdil/cip1/WAF1 in these cells. These results suggest that BCL6 plays a role in keratinocytes at terminal differentiation stage. |
