| First Author | Haymaker CL | Year | 2012 |
| Journal | J Immunol | Volume | 188 |
| Issue | 7 | Pages | 3208-16 |
| PubMed ID | 22351937 | Mgi Jnum | J:183111 |
| Mgi Id | MGI:5317495 | Doi | 10.4049/jimmunol.1103316 |
| Citation | Haymaker CL, et al. (2012) Bone marrow-derived IL-13Ralpha1-positive thymic progenitors are restricted to the myeloid lineage. J Immunol 188(7):3208-16 |
| abstractText | The earliest thymic progenitors (ETPs) were recently shown to give rise to both lymphoid and myeloid cells. Whereas the majority of ETPs are derived from IL-7Ralpha-positive cells and give rise exclusively to T cells, the origin of the myeloid cells remains undefined. In this study, we show both in vitro and in vivo that IL-13Ralpha1(+) ETPs yield myeloid cells with no potential for maturation into T cells, whereas IL-13Ralpha1(-) ETPs lack myeloid potential. Moreover, transfer of lineage-negative IL-13Ralpha1(+) bone marrow stem cells into IL-13Ralpha1-deficient mice reconstituted thymic IL-13Ralpha1(+) myeloid ETPs. Myeloid cells or macrophages in the thymus are regarded as phagocytic cells whose function is to clear apoptotic debris generated during T cell development. However, the myeloid cells derived from IL-13Ralpha1(+) ETPs were found to perform Ag-presenting functions. Thus, IL-13Ralpha1 defines a new class of myeloid restricted ETPs yielding APCs that could contribute to development of T cells and the control of immunity and autoimmunity. |
