Primary Identifier | MGI:7411252 | Allele Type | Endonuclease-mediated |
Attribute String | Humanized sequence | Gene | Adar |
Strain of Origin | C57BL/6J | Is Recombinase | false |
Is Wild Type | false |
molecularNote | CRISPR/Cas9 technology generated a single point mutation resulting in a lysine to asparagine substitution at amino acid 948 (p.K948N). Two silent mutations were also generated. This corresponds to an Aicardi-Goutieres syndrome-causative p.K999N mutation located in a deaminase domain. |