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Allele : Adar<em3Kawy> adenosine deaminase, RNA-specific; endonuclease-mediated mutation 3, Yukio Kawahara

Primary Identifier  MGI:7411252 Allele Type  Endonuclease-mediated
Attribute String  Humanized sequence Gene  Adar
Strain of Origin  C57BL/6J Is Recombinase  false
Is Wild Type  false
molecularNote  CRISPR/Cas9 technology generated a single point mutation resulting in a lysine to asparagine substitution at amino acid 948 (p.K948N). Two silent mutations were also generated. This corresponds to an Aicardi-Goutieres syndrome-causative p.K999N mutation located in a deaminase domain.
  • mutations:
  • Single point mutation
  • synonyms:
  • Adar1<K948N>,
  • Adar1<K948N>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

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0 Driven By

2 Publication categories

Trail: Allele