| First Author | Kawata Y | Year | 1996 |
| Journal | Thromb Haemost | Volume | 76 |
| Issue | 4 | Pages | 569-76 |
| PubMed ID | 8902998 | Mgi Jnum | J:36661 |
| Mgi Id | MGI:84088 | Citation | Kawata Y, et al. (1996) Expression of plasminogen activator inhibitor 2 in the adult and embryonic mouse tissues. Thromb Haemost 76(4):569-76 |
| abstractText | We have studied the expression of plasminogen activator inhibitor 2 (PAI-2) in the adult mouse and during embryonic development using immunohistochemistry and the polymerase-chain reaction. Mouse PAI-2 mRNA was mainly expressed in the skin, bone-marrow, spleen, lung, thymus, and urinary bladder. Immunohistochemical studies suggested that PAI-2 was synthesized in macrophages and epithelial cells such as skin epithelial cells, transitional cells of the urinary bladder, and mesothelial cell of peritoneum and pleura. PAI-2 mRNA and antigen expression was observed only in the skin of 15 day-old mouse embryos. These data suggest that PAI-2 may play a role in protecting the mouse embryo from the protease attack in the amniotic fluid and also in maintaining and/or protecting the structure of various surfaces in the mouse. |
