| Primary Identifier | IPR027714 | Type | Family |
| Short Name | Fyv10/MAEA |
| description | This entry includes the yeast Fyv10 protein and the animal E3 ubiquitin-protein transferase MAEA.Rmd5 and Fyv10 form the heterodimeric E3 ligase unit of the Gid (glucose induced degradation deficient) complex, which is is involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase [, ]. In Saccharomyces cerevisiae, it is required for survival upon exposure to K1 killer toxin [].MAEA is a core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex []. |
