| First Author | Mastroberardino PG | Year | 2002 |
| Journal | Cell Death Differ | Volume | 9 |
| Issue | 9 | Pages | 873-80 |
| PubMed ID | 12181738 | Mgi Jnum | J:115545 |
| Mgi Id | MGI:3691913 | Doi | 10.1038/sj.cdd.4401093 |
| Citation | Mastroberardino PG, et al. (2002) 'Tissue' transglutaminase ablation reduces neuronal death and prolongs survival in a mouse model of Huntington's disease. Cell Death Differ 9(9):873-80 |
| abstractText | By crossing Huntington's disease (HD) R6/1 transgenic mice with 'tissue' transglutaminase (TG2) knock-out mice, we have demonstrated that this multifunctional enzyme plays an important role in the neuronal death characterising this disorder in vivo. In fact, a large reduction in cell death is observed in R6/1, TG2(-/-) compared with R6/1 transgenic mice. In addition, we have shown that the formation of neuronal intranuclear inclusions (NII) is potentiated in absence of the 'tissue' transglutaminase. These phenomena are paralleled by a significant improvement both in motor performances and survival of R6/1, TG2(-/-) versus R6/1 mice. Taken together these findings suggest an important role for tissue transglutaminase in the regulation of neuronal cell death occurring in Huntington's disease. |
