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Protein Coding Gene : Ano2 anoctamin 2
Primary Identifier  MGI:2387214 Organism  mouse, laboratory
Chromosome  6 NCBI Gene Number  243634
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables identical protein binding activity and intracellularly calcium-gated chloride channel activity. Acts upstream of or within chloride transport and establishment of localization in cell. Located in neuron projection; non-motile cilium; and plasma membrane. Is active in glutamatergic synapse and presynaptic membrane. Is expressed in dorsal root ganglion; epidermis; medulla oblongata basal plate mantle layer; olfactory epithelium; and spinal cord mantle layer. Orthologous to human ANO2 (anoctamin 2).
PHENOTYPE: Mice homozygous for a knock-out allele lack calcium-activated chloride currents in the main olfactory epithelium and vomeronasal organ but normal olfaction in behavioral tasks. [provided by MGI curators]
  • synonyms:
  • Ano2,
  • Tmem16b,
  • transmembrane protein 16B,
  • anoctamin 2,
  • MGC:38715,
  • cDNA sequence BC033409,
  • BC033409
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Trail: ProteinCodingGene

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