Primary Identifier | MGI:2181633 | Allele Type | Targeted |
Attribute String | Null/knockout, Reporter | Gene | Otog |
Transmission | Germline | Strain of Origin | 129S2/SvPas |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The majority of exon 1 and all of exons 2 and 3 were replaced with a NLS-lacZ and neo cassette inserted immediately downstream of the endogenous start codon. RT-PCR analysis of inner ear tissue showed an absence of transcript in homozygous mutant mice. Immunohistolabelling was reported to additionally confirm inactivation (data not shown). |