| First Author | Ghilan M | Year | 2018 |
| Journal | Behav Brain Res | Volume | 350 |
| Pages | 72-79 | PubMed ID | 29778627 |
| Mgi Jnum | J:262612 | Mgi Id | MGI:6163347 |
| Doi | 10.1016/j.bbr.2018.05.012 | Citation | Ghilan M, et al. (2018) Impaired spatial processing in a mouse model of fragile X syndrome. Behav Brain Res 350:72-79 |
| abstractText | Fragile X syndrome (FXS) is the most common form of inherited intellectual impairment. The Fmr1(-/y) mouse model has been previously shown to have deficits in context discrimination tasks but not in the elevated plus-maze. To further characterize this FXS mouse model and determine whether hippocampal-mediated behaviours are affected in these mice, dentate gyrus (DG)-dependent spatial processing and Cornu ammonis 1 (CA1)-dependent temporal order discrimination tasks were evaluated. In agreement with previous findings of long-term potentiation deficits in the DG of this transgenic model of FXS, the results reported here demonstrate that Fmr1(-/y) mice perform poorly in the DG-dependent metric change spatial processing task. However, Fmr1(-/y) mice did not present deficits in the CA1-dependent temporal order discrimination task, and were able to remember the order in which objects were presented to them to the same extent as their wild-type littermate controls. These data suggest that the previously reported subregional-specific differences in hippocampal synaptic plasticity observed in the Fmr1(-/y) mouse model may manifest as selective behavioural deficits in hippocampal-dependent tasks. |
