| First Author | Pesce M | Year | 1998 |
| Journal | Bioessays | Volume | 20 |
| Issue | 9 | Pages | 722-32 |
| PubMed ID | 9819561 | Mgi Jnum | J:49703 |
| Mgi Id | MGI:1298185 | Doi | 10.1002/(SICI)1521-1878(199809)20:9<722::AID-BIES5>3.0.CO;2-I |
| Citation | Pesce M, et al. (1998) In line with our ancestors: Oct-4 and the mammalian germ. Bioessays 20(9):722-32 |
| abstractText | The transcription factor Oct-4 is expressed specifically in the totipotent germline cycle of mice. Cells that lose Oct-4 differentiate along different paths to form embryonic and extraembryonic somatic tissue. Oct-4 may maintain the potency of stem and germline cells by preventing all other differentiation pathways. Oct-4 may also regulate the molecular differentiation of cells in the germ lineage as it progresses from the fertilized egg, through cleavage stage/morula blastomeres, blastocyst, inner cell mass, epiblast, germ cells, and gametes. The factors that regulate, and are regulated by, Oct-4 are reviewed with respect to the phenomena of cell potency and germ/soma segregation and differentiation. |
