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Protein Coding Gene : Ythdf1 YTH N6-methyladenosine RNA binding protein 1

Primary Identifier  MGI:1917431 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  228994
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables N6-methyladenosine-containing RNA reader activity. Involved in several processes, including learning or memory; post-transcriptional regulation of gene expression; and regulation of long-term synaptic potentiation. Located in cytoplasm. Is expressed in brain; future spinal cord; intestine; liver; and spinal cord. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human YTHDF1 (YTH N6-methyladenosine RNA binding protein F1).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit learning and memory defects as well as impaired hippocampal synaptic transmission and long-term potentiation. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA 2210410K23 gene,
  • Ythdf1,
  • YTH N6-methyladenosine RNA binding protein 1,
  • 2210410K23Rik

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1 Transgenic Expressors

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