| First Author | Lee JS | Year | 1989 |
| Journal | Somat Cell Mol Genet | Volume | 15 |
| Issue | 2 | Pages | 143-52 |
| PubMed ID | 2784591 | Mgi Jnum | J:9685 |
| Mgi Id | MGI:58142 | Doi | 10.1007/BF01535075 |
| Citation | Lee JS, et al. (1989) The IL-4 and IL-5 genes are closely linked and are part of a cytokine gene cluster on mouse chromosome 11. Somat Cell Mol Genet 15(2):143-52 |
| abstractText | The murine IL-4 and IL-5 genes encode hemopoietic growth factors involved in the stimulation, proliferation, and differentiation of cells of the T lymphocyte, B lymphocyte, and granulocyte lineages. We have mapped the Il-4 and Il-5 loci representing the structural genes for IL-4 and IL-5, respectively, to mouse chromosome 11 using Chinese hamster x mouse and rat x mouse somatic cell hybrids. Physical linkage studies of the IL-4 and IL-5 genes by pulsed field gel electrophoresis have shown that they are closely linked, being 110-180 kb apart. Since the Il-5 locus maps to the interface of bands A5 and B1 in the same location as the genes for IL-3 and GM-CSF, this places these three cytokine genes, as well as the IL-4 gene, within a region of about 5000-10,000 kb. The present physical linkage studies indicate that the IL-4 and IL-5 genes are a minimum of 600 kb apart from the closely linked IL-3 and GM-CSF genes. The gene clustering, together with similarities in gene structure, regulation, and biological function, raises the possibility that the four genes may be part of a distantly related cytokine gene family. |
