| First Author | Liu D | Year | 2019 |
| Journal | Immunity | Volume | 51 |
| Issue | 1 | Pages | 64-76.e7 |
| PubMed ID | 31231033 | Mgi Jnum | J:281024 |
| Mgi Id | MGI:6376394 | Doi | 10.1016/j.immuni.2019.05.011 |
| Citation | Liu D, et al. (2019) IL-10-Dependent Crosstalk between Murine Marginal Zone B Cells, Macrophages, and CD8alpha(+) Dendritic Cells Promotes Listeria monocytogenes Infection. Immunity 51(1):64-76.e7 |
| abstractText | Type 1 CD8alpha(+) conventional dendritic cells (cDC1s) are required for CD8(+) T cell priming but, paradoxically, promote splenic Listeria monocytogenes infection. Using mice with impaired cDC2 function, we ruled out a role for cDC2s in this process and instead discovered an interleukin-10 (IL-10)-dependent cellular crosstalk in the marginal zone (MZ) that promoted bacterial infection. Mice lacking the guanine nucleotide exchange factor DOCK8 or CD19 lost IL-10-producing MZ B cells and were resistant to Listeria. IL-10 increased intracellular Listeria in cDC1s indirectly by reducing inducible nitric oxide synthase expression early after infection and increasing intracellular Listeria in MZ metallophilic macrophages (MMMs). These MMMs trans-infected cDC1s, which, in turn, transported Listeria into the white pulp to prime CD8(+) T cells. However, this also facilitated bacterial expansion. Therefore, IL-10-mediated crosstalk between B cells, macrophages, and cDC1s in the MZ promotes both Listeria infection and CD8(+) T cell activation. |
