Primary Identifier | MGI:5634714 | Allele Type | Transgenic |
Attribute String | Constitutively active, Inserted expressed sequence | Gene | Tg(tetO-Mtor*)#Atai |
Strain of Origin | C57BL/6 | Is Recombinase | false |
Is Wild Type | false |
molecularNote | This transgene consists of the tetracycline-responsive element and the mutant rat Mtor kinase, which harbors four point mutations in the FKBP12-rapamycin binding and kinase domains (V2198A, L2216H, L2260P, and I2017T) with a FLAG tag at the N terminus. Expression of active Mtor depends on binding of tTA to the tetO promoter. The pound symbol (#) is used when line is not specified and/or lines are pooled. |