| First Author | Shkolnik K | Year | 2007 |
| Journal | FEBS Lett | Volume | 581 |
| Issue | 25 | Pages | 4891-8 |
| PubMed ID | 17900570 | Mgi Jnum | J:126926 |
| Mgi Id | MGI:3762313 | Doi | 10.1016/j.febslet.2007.09.016 |
| Citation | Shkolnik K, et al. (2007) A novel ovary-specific and ovulation-associated variant of epoxide hydrolase 2. FEBS Lett 581(25):4891-8 |
| abstractText | Ovulation is a complex process initiated by the surge of the pituitary luteinizing hormone (LH) that provokes the expression of specific genes. We report herein the isolation and characterization of an ovulation-associated, ovary-specific novel isoform of epoxide hydrolase 2 (Ephx2), Ephx2C. This variant is exclusively expressed in the granulosa cells of preovulatory mouse ovarian follicles. The LH-induced expression of Ephx2C is mediated by the protein kinase A and partially by the protein kinase C signaling pathways. The involvement of p38 kinase has also been demonstrated. |
