| First Author | Jeon HM | Year | 2008 |
| Journal | Genes Dev | Volume | 22 |
| Issue | 15 | Pages | 2028-33 |
| PubMed ID | 18676808 | Mgi Jnum | J:139492 |
| Mgi Id | MGI:3808623 | Doi | 10.1101/gad.1668708 |
| Citation | Jeon HM, et al. (2008) Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling. Genes Dev 22(15):2028-33 |
| abstractText | Cellular origins and genetic factors governing the genesis and maintenance of glioblastomas (GBM) are not well understood. Here, we report a pathogenetic role of the developmental regulator Id4 (inhibitor of differentiation 4) in GBM. In primary murine Ink4a/Arf(-/-) astrocytes, and human glioma cells, we provide evidence that enforced Id4 can drive malignant transformation by stimulating increased cyclin E to produce a hyperproliferative profile and by increased Jagged1 expression with Notch1 activation to drive astrocytes into a neural stem-like cell state. Thus, Id4 plays an integral role in the transformation of astrocytes via its combined actions on two-key cell cycle and differentiation regulatory molecules. |
