| Primary Identifier | MGI:5304912 | Allele Type | Targeted |
| Attribute String | Inducible, Recombinase | Gene | Notch1 |
| Transmission | Germline | Strain of Origin | C57BL/6NTac |
| Induced With | tamoxifen | Is Recombinase | true |
| Is Wild Type | false |
| molecularNote | A targeting vector was constructed to insert the cre/ERT2 coding sequence, a polyadenylation signal and an Frt-flanked neo selection cassette in-frame with the start codon of Notch 1, by homologous recombination in ES cells. This resulted in deletion of most of exon 1. Chimeric males were bred to Flpe-expressing females to remove the selection cassette. Mice homozygous for this allele die embryonically. |
