| First Author | Shanley JD | Year | 1994 |
| Journal | J Infect Dis | Volume | 169 |
| Issue | 5 | Pages | 1088-91 |
| PubMed ID | 8169397 | Mgi Jnum | J:17837 |
| Mgi Id | MGI:65863 | Doi | 10.1093/infdis/169.5.1088 |
| Citation | Shanley JD, et al. (1994) The role of tumor necrosis factor-alpha in acute murine cytomegalovirus infection in BALB/c mice. J Infect Dis 169(5):1088-91 |
| abstractText | The role of tumor necrosis factor-alpha (TNF alpha) in acute lethal and sublethal murine cytomegalovirus (MCMV) infection in BALB/c mice was examined. During the course of acute infection, TNF alpha was not detectable in the serum or bronchoalveolar lavage (BAL) fluids, while TNF alpha was uniformly detected in both serum and BAL following intravenous administration of lipopolysaccharide (LPS). Administration of recombinant murine (rMu) TNF alpha did not consistently alter the virus content of tissues during acute infection. Passive transfer of purified polyclonal immunoglobulin containing neutralizing antibody to TNF alpha did not alter mortality or MCMV replication in tissues during acute infection but did block the TNF alpha response when LPS was administered to BALB/c mice. Thus, TNF alpha appears to play little role in the course and outcome of acute MCMV infection. |
