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Publication : Ordering of mouse immunoglobulin heavy chain genes by molecular cloning.

First Author  Shimizu A Year  1981
Journal  Nature Volume  289
Issue  5794 Pages  149-53
PubMed ID  6779206 Mgi Jnum  J:6456
Mgi Id  MGI:54932 Doi  10.1038/289149a0
Citation  Shimizu A, et al. (1981) Ordering of mouse immunoglobulin heavy chain genes by molecular cloning. Nature 289(5794):149-53
abstractText  We have determined the order of the mouse immunoglobulin gamma 1, gamma 2 b, gamma 2 a and epsilon genes by molecular cloning of overlapping chromosomal segments. The results clearly demonstrate that the order is 5'-gamma 1-(21 kilobases)-gamma 2b-(15 kilobases)-gamma 2a-(15 kilobases)-epsilon-3'. There seem to be no J regions at the 5' side of each constant region gene so far obtained except for the mu gene and these constant region genes seem to have repetitive sequences characteristic of switch (S) regions at their 5' side.
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