| First Author | Fraidakis MJ | Year | 2007 |
| Journal | Neuroreport | Volume | 18 |
| Issue | 2 | Pages | 185-9 |
| PubMed ID | 17301687 | Mgi Jnum | J:120345 |
| Mgi Id | MGI:3706297 | Doi | 10.1097/WNR.0b013e328011516a |
| Citation | Fraidakis MJ, et al. (2007) Recovery from spinal cord injury in tumor necrosis factor-alpha, signal transducers and activators of transcription 4 and signal transducers and activators of transcription 6 null mice. Neuroreport 18(2):185-9 |
| abstractText | Tumor necrosis factor-alpha is a central cytokine involved in the regulation of the innate immune response. Signal transducers and activators of transcription 4 and signal transducers and activators of transcription 6 are second messengers mediating the Th1 and Th2-specific immune responses, respectively. We studied the outcome of spinal cord injury with respect to the locomotion and axonal regeneration in tumor necrosis factor-alpha, signal transducers and activators of transcription 4 and signal transducers and activators of transcription 6 knockout mice. Locomotor behavior after injury differed between mouse strains, but not between wild-type and the knockout genotypes of the same strain. Regeneration of descending tracts, assessed by fluorogold/fluororuby retrograde double-labeling, however, appeared hampered by Th2 deficiency. |
