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Protein Coding Gene : Irgc immunity related GTPase cinema
Primary Identifier  MGI:2685948 Organism  mouse, laboratory
Chromosome  7 NCBI Gene Number  210145
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable GTPase activity. Involved in positive regulation of flagellated sperm motility. Located in lipid droplet and sperm mitochondrial sheath. Orthologous to human IRGC (immunity related GTPase cinema).
PHENOTYPE: Mice homozygous for a null allele exhibit reduced male fertility associated with short sperm flagellum, decreased sperm progressive motility, impaired sperm penetration of zona pellucida, and disorganized sperm fibrous sheath morphology. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA F630044M05 gene,
  • F630044M05Rik,
  • Irgc1,
  • immunity related GTPase cinema,
  • gene model 1102, (NCBI),
  • LOC381989,
  • Gm474,
  • interferon inducible GTPase family member 5,
  • immunity-related GTPase family, cinema 1,
  • gene model 474, (NCBI),
  • immunity related GTPase cinema 1,
  • Gm1102,
  • Iigp5,
  • LOC210145,
  • MGI:2685320,
  • Irgc
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