Primary Identifier | IPR041177 | Type | Domain |
Short Name | GEN1_C |
description | This is the C-terminal domain found in GEN1 resolvase. It is composed of three-strand antiparallel beta sheets and four alpha helices []. GEN1 protein, a member of the XPG/Rad2 family of structure-selective endonucleases, is specialized for the cleavage of Holliday junction recombination intermediates []. Structural comparison indicates that the C-terminal domain is similar to a series of chromobox homology proteins []. Functional analysis indicates that the chromodomain provides an additional DNA binding site necessary for efficient HJ cleavage, and its truncation severely hampers GEN1's catalytic activity []. |