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Allele : Brca1<tm3Jjon> breast cancer 1, early onset; targeted mutation 3, Jos Jonkers
Primary Identifier  MGI:5823772 Allele Type  Targeted
Attribute String  Null/knockout Gene  Brca1
Transmission  Germline Strain of Origin  Not Specified
Is Recombinase  false Is Wild Type  false
molecularNote  Nonchemically modified deoxyribonucleotides were used to introduce the (5-CAAGGCGATCCAGAGAATCAGGACCGGGAAAAGGTAAAGTC-3) mutation into a mouse ES cell line. This alteration is an insertion of 4 nucleotides (AGGA) to generate the Brca15382stop mutation, which resulted in premature protein truncation at aa 1713 and closely resembled the human BRCA15382insC mutation.
  • mutations:
  • Nucleotide substitutions
  • synonyms:
  • Brca1<5382stop>,
  • Brca1<5382stop>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

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0 Driven By

4 Publication categories

Trail: Allele




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