Primary Identifier | MGI:3711006 | Allele Type | Targeted |
Attribute String | Conditional ready, No functional change | Gene | Braf |
Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
Is Recombinase | false | Is Wild Type | false |
description | Phenotypic Similarity to Human Syndrome: Neurocardiofaciocutaneous syndromes ( J:144862) |
molecularNote | LoxP sites were inserted to flank exon 3 according to nomenclature in J:29234. An FRT-flanked neomycin resistance cassette was removed prior to ES cell injection. Deletion of exon 3 would cause a reading frame shift and introduce a translational stop codon at position 132, truncating the RBD, CRD and kinase domains. |