| First Author | Zerr P | Year | 2000 |
| Journal | Neurogenetics | Volume | 2 |
| Issue | 4 | Pages | 231-4 |
| PubMed ID | 10983719 | Mgi Jnum | J:82183 |
| Mgi Id | MGI:2651738 | Doi | 10.1007/pl00022974 |
| Citation | Zerr P, et al. (2000) The murine Bis1 seizure gene and the Kcnab2 gene encoding the beta2-subunit of the K+ channel are different. Neurogenetics 2(4):231-4 |
| abstractText | We tested the hypothesis that Bis1, a gene involved in seizure regulation in mice which has been localized to the distal part of chromosome 4, was the same as the gene Kcnab2, encoding the beta2-subunit for voltage-dependent K+ channels. Two facts suggested this hypothesis: Kcnab2 is located in the 3.1-cM confidence interval containing Bis1 and many studies have shown an involvement of K+ channels in the genesis of seizures. DNA sequence analysis of the coding sequence for Kcnab2 from JE/Le mice revealed no structural alterations which might affect Kcnab2 function. However, several nucleotide changes were observed. |
