| First Author | du Cros DL | Year | 1993 |
| Journal | Dev Biol | Volume | 156 |
| Issue | 2 | Pages | 444-53 |
| PubMed ID | 8462743 | Mgi Jnum | J:4655 |
| Mgi Id | MGI:53138 | Doi | 10.1006/dbio.1993.1091 |
| Citation | du Cros DL (1993) Fibroblast growth factor influences the development and cycling of murine hair follicles. Dev Biol 156(2):444-53 |
| abstractText | The effects of basic fibroblast growth factor (bFGF) on the development of hair follicles in neonatal mouse skin were examined. Newborn mice (B6C3-based strain) were given daily subcutaneous injections of bFGF and bovine serum albumin (BSA) for 7 days. By Day 9, distinct areas of hairless, unpigmented skin were observed surrounding the sites treated with bFGF. This phenomenon persisted until about 14-16 days of age when the emergence of hair in the bald patches was first seen. Hair growth continued in the treated regions until they were mostly covered at 18-20 days of postnatal age. Control sites injected with BSA only were indistinguishable from the surrounding pigmented, hairy skin at all ages. Histological examination of skin from various ages of bFGF-treated mice suggested that the growth factor had affected both the initiation and the development of the hair follicles. This resulted in a significant delay in the first and subsequent hair cycles when compared to control animals injected with BSA only. |
