Primary Identifier | MGI:2388386 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Drd2 |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A 3' portion of exon 2 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded the amino terminal extracellular domain, transmembrane spanning domains 1 and 2, and the first intracellular domain. Transcript was undetected by Northern blot analysis of RNA obtained from the dorsal striatum of homozygous mutant mice. |