| First Author | Zhong W | Year | 1996 |
| Journal | Neuron | Volume | 17 |
| Issue | 1 | Pages | 43-53 |
| PubMed ID | 8755477 | Mgi Jnum | J:34328 |
| Mgi Id | MGI:81788 | Doi | 10.1016/s0896-6273(00)80279-2 |
| Citation | Zhong W, et al. (1996) Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis. Neuron 17(1):43-53 |
| abstractText | During Drosophila neurogenesis, differential segregation of Numb is necessary for daughter cells of asymmetric divisions to adopt distinct fates, at least partly by biasing the Notch-mediated cell-cell interaction. We have isolated a highly conserved mammalian homolog of Drosophila numb, m-numb. During mouse cortical neurogenesis, m-Numb is asymmetrically localized to the apical membrane of dividing ventricular neural progenitors. Depending upon the orientation of the cleavage plane, m-Numb may be distributed into one or both of the daughter cells. When expressed in Drosophila embryos, m-Numb is localized asymmetrically in dividing neural precursors and rescues the numb mutant phenotype. Futhermore, m-Numb can physically interact with mouse Notch1. We propose that some shared molecular mechanisms, both cell-intrinsic and cell-extrinsic, generate asymmetric cell divisions during neurogenesis of vertebrates and invertebrates. |
