| First Author | Guo A | Year | 2000 |
| Journal | Nat Cell Biol | Volume | 2 |
| Issue | 10 | Pages | 730-6 |
| PubMed ID | 11025664 | Mgi Jnum | J:119165 |
| Mgi Id | MGI:3701394 | Doi | 10.1038/35036365 |
| Citation | Guo A, et al. (2000) The function of PML in p53-dependent apoptosis. Nat Cell Biol 2(10):730-6 |
| abstractText | The PML gene of acute promyelocytic leukaemia (APL) encodes a growth- and tumour-suppresor protein that is essential for several apoptotic signals. The mechanisms by which PML exerts its pro-apoptotic function are still unknown. Here we show that PML acts as a transcriptional co-activator with p53. PML physically interacts with p53 both in vitro and in vivo and co-localizes with p53 in the PML nuclear body (PML-NB). The co-activatory role of PML depends on its ability to localize in the PML-NB. p53-dependent, DNA-damage-induced apoptosis, transcriptional activation by p53, the DNA-binding ability of p53, and the induction of p53 target genes such as Bax and p21 upon gamma-irradiation are all impaired in PML-/- primary cells. These results define a new PML-dependent, p53-regulatory pathway for apoptosis and shed new light on the function of PML in tumour suppression. |
