| First Author | Bikkavilli RK | Year | 2011 |
| Journal | J Cell Sci | Volume | 124 |
| Issue | Pt 13 | Pages | 2310-20 |
| PubMed ID | 21652632 | Mgi Jnum | J:183055 |
| Mgi Id | MGI:5317392 | Doi | 10.1242/jcs.084046 |
| Citation | Bikkavilli RK, et al. (2011) Arginine methylation of G3BP1 in response to Wnt3a regulates beta-catenin mRNA. J Cell Sci 124(Pt 13):2310-20 |
| abstractText | Wnt/beta-catenin signaling is essential for normal mammalian development. Wnt3a activates the Wnt/beta-catenin pathway through stabilization of beta-catenin; a process in which the phosphoprotein Dishevelled figures prominently. Protein arginine methylation in signaling complexes containing Dishevelled was investigated. Mass spectrometry of a prominent arginine-methylated, Dishevelled-associated protein identified the Ras GTPase activating protein-binding protein 1 G3BP1. Stimulation of totipotent mouse embryonic F9 cells with Wnt3a provoked increased methylation of G3BP1. We show that G3BP1 is a novel Ctnnb1 mRNA binding protein. Methylation of G3BP1 constitutes a molecular switch that regulates Ctnnb1 mRNA in response to Wnt3a. Thus, the protein arginine methylation that targets G3BP1 acts as a novel regulator of Ctnnb1 mRNA. |
