| First Author | Fontaine RN | Year | 1996 |
| Journal | Mol Cell Biochem | Volume | 159 |
| Issue | 2 | Pages | 149-53 |
| PubMed ID | 8858565 | Mgi Jnum | J:35197 |
| Mgi Id | MGI:82651 | Doi | 10.1007/BF00420917 |
| Citation | Fontaine RN, et al. (1996) Liver and intestinal fatty acid binding proteins in control and TGF beta 1 gene targeted deficient mice. Mol Cell Biochem 159(2):149-53 |
| abstractText | The effect of transforming growth factor beta-1 (TGF beta 1) expression on fatty acid binding proteins was examined in control and two strains of gene targeted TGF beta 1-deficient mice. Homozygous TGF beta 1-deficient 129 x CF-1, expressing multifocal inflammatory syndrome, had 25% less liver fatty acid binding protein (L-FABP) when compared to control mice. The decrease in L-FABP expression was not due to multifocal inflammatory syndrome since homozygous TGF beta 1-deficient/immunodeficient C3H mice on a SCID background had 36% lower liver L-FABP than controls. This effect was developmentally related and specific to liver, but not the proximal intestine, where L-FABP is also expressed. Finally, the proximal intestine also expresses intestinal-FABP (I-FABP) which decreased 3-fold in the TGF beta 1-deficient/immunodeficient C3H mice only. Thus, TGF beta 1 appears to regulate the expression of L-FABP and I-FABP in the liver and the proximal intestine, respectively. |
