| First Author | Scherbik SV | Year | 2007 |
| Journal | Virology | Volume | 368 |
| Issue | 2 | Pages | 232-7 |
| PubMed ID | 17904183 | Mgi Jnum | J:175365 |
| Mgi Id | MGI:5285253 | Doi | 10.1016/j.virol.2007.08.017 |
| Citation | Scherbik SV, et al. (2007) Knock-in of the Oas1b(r) allele into a flavivirus-induced disease susceptible mouse generates the resistant phenotype. Virology 368(2):232-7 |
| abstractText | Inheritance patterns in mice suggested that resistance to flavivirus-induced disease was conferred by a single autosomal dominant allele (Flv(r)). A positional cloning strategy followed by comparison of Flv interval gene sequences from congenic resistant C3H.PRI-Flv(r) and susceptible C3H/He mouse strains identified the 2'-5'-oligoadenylate synthetase 1b (Oas1b) gene as Flv. However, since these mouse strains differ by a 31 cM region, the possible involvement of differences in other linked genes in the resistant phenotype could not be absolutely ruled out. Knock-in of the Oas1b resistance allele into a susceptible mouse strain produced mice with the flavivirus resistance phenotype, confirming that this phenotype is mediated by a single gene. |
