| First Author | Parihar A | Year | 2008 |
| Journal | Life Sci | Volume | 82 |
| Issue | 21-22 | Pages | 1077-82 |
| PubMed ID | 18456285 | Mgi Jnum | J:180574 |
| Mgi Id | MGI:5306580 | Doi | 10.1016/j.lfs.2008.03.019 |
| Citation | Parihar A, et al. (2008) mAtNOS1 induces apoptosis of human mammary adenocarcinoma cells. Life Sci 82(21-22):1077-82 |
| abstractText | mAtNOS1 is a novel gene recently reported in mammalian genome with functions that are not fully understood. The present study shows that in human mammary adenocarcinoma MCF-7 cells, mAtNOS1 expression increases mitochondrial nitric oxide and calcium. Our study further shows that overexpression of mAtNOS1 induces apoptosis in MCF-7 cells by increasing mitochondrial protein tyrosine nitration and cytochrome c release. The present study suggests a novel function for mAtNOS1 in regulating mitochondrial nitric oxide and calcium and inducing apoptosis of MCF-7 cells. |
