| First Author | Matsuda M | Year | 2001 |
| Journal | Biochem Biophys Res Commun | Volume | 280 |
| Issue | 2 | Pages | 535-40 |
| PubMed ID | 11162551 | Mgi Jnum | J:70982 |
| Mgi Id | MGI:2148894 | Doi | 10.1006/bbrc.2000.4149 |
| Citation | Matsuda M, et al. (2001) Molecular cloning of a novel ubiquitin-like protein, UBIN, that binds to ER targeting signal sequences. Biochem Biophys Res Commun 280(2):535-40 |
| abstractText | To identify proteins that interact with HSP47, an endoplasmic reticulum (ER)-resident molecular chaperone, a yeast two-hybrid screening was performed using mouse full-length HSP47 including an N-terminal signal sequence as a bait. Analysis of several positive clones led to the identification and cloning of a novel gene, ubin, encoding a ubiquitin-like protein. Unlike other ubiquitin-like proteins, UBIN was shown to interact with signal sequences of various secretory and ER-luminal proteins, including HSP47, but not interact with signal sequences of mitochondrial targeting in two-hybrid system. The possible function of UBIN will be discussed with regards to novel characteristics of binding to signal sequences for ER targeting. Copyright 2001 Academic Press. |
