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Allele : Serpine1<tm1c(EUCOMM)Hmgu> serine (or cysteine) peptidase inhibitor, clade E, member 1; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH

Primary Identifier  MGI:6194589 Allele Type  Targeted
Attribute String  Conditional ready, No functional change Gene  Serpine1
Transmission  Germline Strain of Origin  C57BL/6N-A<tm1Brd>
Is Recombinase  false Is Wild Type  false
Project Collection  EUCOMM
molecularNote  The L1L2_Bact_P cassette was inserted at a position on Chromosome 5 upstream of exon 4 of the gene. The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the FRT-flanked beta-gal/neomycin resistance cassette leaving exons 4 and 5 floxed.
  • mutations:
  • Insertion
  • synonyms:
  • PAI-1<flox>,
  • PAI-1<flox>,
  • PAI-1 CKO,
  • PAI-1 CKO
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

4 Publication categories

Trail: Allele