| First Author | Wijesekara N | Year | 2005 |
| Journal | Mol Cell Biol | Volume | 25 |
| Issue | 3 | Pages | 1135-45 |
| PubMed ID | 15657439 | Mgi Jnum | J:95993 |
| Mgi Id | MGI:3528532 | Doi | 10.1128/MCB.25.3.1135-1145.2005 |
| Citation | Wijesekara N, et al. (2005) Muscle-specific Pten deletion protects against insulin resistance and diabetes. Mol Cell Biol 25(3):1135-45 |
| abstractText | Pten (phosphatase with tensin homology), a dual-specificity phosphatase, is a negative regulator of the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway. Pten regulates a vast array of biological functions including growth, metabolism, and longevity. Although the PI3K/Akt pathway is a key determinant of the insulin-dependent increase in glucose uptake into muscle and adipose cells, the contribution of this pathway in muscle to whole-body glucose homeostasis is unclear. Here we show that muscle-specific deletion of Pten protected mice from insulin resistance and diabetes caused by high-fat feeding. Deletion of muscle Pten resulted in enhanced insulin-stimulated 2-deoxyglucose uptake and Akt phosphorylation in soleus but, surprisingly, not in extensor digitorum longus muscle compared to littermate controls upon high-fat feeding, and these mice were spared from developing hyperinsulinemia and islet hyperplasia. Muscle Pten may be a potential target for treatment or prevention of insulin resistance and diabetes. |
