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Protein Coding Gene : Mink1 misshapen-like kinase 1 (zebrafish)
Primary Identifier  MGI:1355329 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  50932
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables ATP binding activity and protein serine/threonine kinase activity. Involved in brain development; positive regulation of JNK cascade; and positive regulation of p38MAPK cascade. Acts upstream of or within negative thymic T cell selection. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm. Is expressed in knee joint primordium; knee mesenchyme; lower leg mesenchyme; tibia; and tibia cartilage condensation. Orthologous to human MINK1 (misshapen like kinase 1).
PHENOTYPE: Mice homozygous for a null allele display increased bleeding times and impaired platelet aggregation and dense granule secretion. [provided by MGI curators]
  • synonyms:
  • Yeast Sps1/Ste20-related kinase 2 (S. cerevisiae),
  • MGI:1203526,
  • Mink1,
  • misshapen-like kinase 1 (zebrafish),
  • mitogen-activated protein kinase kinase kinase kinase 6,
  • Misshapen/NIKs-related kinase,
  • MINK,
  • Map4k6,
  • Ysk2
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2 Involved In Mutations

Trail: ProteinCodingGene

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

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Canonical gene --> Transcripts in specific strains.

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4 Pathways

Trail: ProteinCodingGene

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Genes/Features --> Phenotypes (MP terms)

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